Platelet Assay

There’s reason to explore platelet activity when immune profiling any drug. Intentionally or unintentionally, a drug that triggers platelet activity unfolds a dramatic chain of events. Platelets are metabolically active cellular fragments, having no nuclei but a large number of surface receptors and granules. When their surface receptors are upregulated, platelets undergo a change in appearance, acquiring an irregular shape and a massive surface area that facilitates platelet aggregation. In addition, upregulation triggers the release of granule content, which includes ADP and other molecules that activate still more platelets – thus reinforcing the reaction. It’s no wonder that undesired thrombosis can appear so suddenly. Nonetheless, thrombosis may be just one platelet-related risk to clinical subjects.

Reach out to us to discuss how platelet analysis fits into your preclinical program.

“Our Lab Team have experience in different platelet assessments including platelet activation, aggregation, and apoptosis as well as hemolysis and hemagglutination”

Given the complexity of platelets’ role in the body, it’s vital to examine their activation with a physiologically relevant model. Immuneed’s test system, ID Flow is an excellent way of accounting for platelet, blood, and immune system intricacy. A dynamic model that mimics human blood circulation, it uses fresh blood from healthy subjects, rather than isolated cells removed from their complex environment. All blood components and cascade systems are intact, which means the many interactions and amplifications can be observed. Moreover, since blood enters the ID.Flow platform immediately, it doesn’t have to be pretreated with high levels of anticoagulants, as it would for in-vitro analysis